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ea0037gp.15.01 | Diabetes and obesity – basic | ECE2015

Topical application of CD362⁺ human mesenchymal stem cells (cyndacel-M) seeded in Excellagen scaffold augments wound healing and increases angiogenesis in a diabetic rabbit ulcer model

Patil Swapnil , Chen Xizhe , Watson Luke , Loftus Paul , Flynn Lisa O' , Chandler Lois , Rubanyi Gabor , Elliman Stephen , O'Brien Timothy

Non-healing foot ulcers are a major complication in diabetic patients. Mesenchymal stem cells (MSCs) are known to promote angiogenesis with improved wound healing. Orbsen Therapeutics has identified a novel antibody (CD362+) which can be used to prospectively FACS-isolate CD362+CD45− MSC from human bone marrow with enhanced MSC/MNC purity ratios of up to 1/4. Excellagen matrix was used to seed the cells as biomaterials are well reported t...

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Endocrine Abstracts

Topical application of CD362⁺ human mesenchymal stem cells (cyndacel-M) seeded in Excellagen scaffold augments wound healing and increases angiogenesis in a diabetic rabbit ulcer model

BiosciAbstracts

Endocrine Abstracts

Topical application of CD362+ human mesenchymal stem cells (cyndacel-M) seeded in Excellagen scaffold augments wound healing and increases angiogenesis in a diabetic rabbit ulcer model

BiosciAbstracts

Topical application of CD362⁺ human mesenchymal stem cells (cyndacel-M) seeded in Excellagen scaffold augments wound healing and increases angiogenesis in a diabetic rabbit ulcer model